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Rosiglitazone (ROS-e-glit-a-zone) is used in the management of type 2 diabetes mellitus. It is an oral antidiabetic agent which acts primarily by increasing insulin sensitivity. Rosiglitazone improves glycemic control while reducing circulating insulin levels. Rosiglitazone works differently than some other diabetes medicines. It does not cause your body to make more insulin. Instead, Rosiglitazone can help your body use its natural insulin better. This lowers your blood sugar and can help keep it under control.

How to take

Take Rosiglitazone orally with or without food. Continue to take Rosiglitazone even if you feel well. Do not miss any doses. Taking Rosiglitazone at the same time each day will help you remember to take it. Rosiglitazone can be administrated once or twice daily with or without food. Follow the directions of your health care professional while taking Rosiglitazone.

Side effects

More common side effects may include: headache, high blood sugar, low blood sugar, back pain, fatigue, respiratory tract infections, sinus inflammation, swelling. Check with your doctor if any of these most common side effects persist or become bothersome: headache; weight gain. Less common side effects may include: anemia (low blood cell count); diarrhea. Seek medical attention right away if any of these severe side effects occur: Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision or other vision changes; chest pain; fainting; numbness of an arm or leg; severe headache, stomach pain, or vomiting; symptoms of heart failure (eg, shortness of breath; sudden unexplained weight gain; swelling of the hands, ankles, or feet); symptoms of liver problems (eg, dark urine; yellowing of the skin or eyes; unexplained nausea, vomiting, or loss of appetite; stomach pain); symptoms of low blood sugar (eg, anxiety, increased sweating, dizziness or drowsiness, headache, chills, tremors, increased hunger); unusual bone pain; unusual tiredness or weakness. Symptoms of overdose with Rosiglitazone are signs of low blood sugar, such as hunger, headache, confusion, irritability, drowsiness, weakness, dizziness, tremors, sweating, fast heartbeat, seizure (convulsions), fainting, or coma. If an overdose is suspected call your doctor or emergency room immediately. Your doctor should check your eyes regularly. Very rarely, some people have experienced vision changes due to swelling in the back of the eye while taking Rosiglitazone.


Do not use Rosiglitazone if: you are allergic to any ingredient in Rosiglitazone; you have moderate to severe heart failure; you have type 1 diabetes; you have a history of liver problems, including jaundice (yellowing of the skin or eyes), during therapy with a similar medicine called troglitazone; you are taking nitrates (such as nitroglycerin) or using insulin. Some medical conditions may interact with Rosiglitazone. Tell your doctor if you have any medical conditions, especially if any of the following apply to you: If you are pregnant, planning to become pregnant, or are breast-feeding; If you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement; If you have allergies to medicines, foods, or other substances; If you have diabetic ketoacidosis; If you have a history of liver problems, abnormal liver function tests, heart problems (eg, congestive heart failure), or eye or vision problems; If you have swelling problems (edema). Rosiglitazone may cause dizziness. This effect may worsen if you take it with alcohol or certain medicines. Use Rosiglitazone with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it. Carry an ID card at all times that says you have diabetes.

Proper diet and exercise are important for best results with Rosiglitazone. Follow the diet and exercise program given to you by your health care provider. It may take 2 weeks for Rosiglitazone to start to lower your blood sugar. It may take up to 3 months to see the full effect of Rosiglitazone. If your symptoms do not get better within 2 weeks or if they get worse, check with your doctor. Check your blood sugar levels as directed by your doctor. If they are often higher than they should be and you take Rosiglitazone exactly as prescribed, tell your doctor. Rosiglitazone may cause low blood sugar levels when it is used along with insulin or other oral diabetic medicines. Tell your doctor right away if this happens. Rosiglitazone may cause ovulation in women who have not reached menopause but do not ovulate. Be sure to use effective birth control while using Rosiglitazone. Tell your doctor or dentist that you take Rosiglitazone before you receive any medical or dental care, emergency care, or surgery. An increased incidence of bone fracture has been reported in women who take Rosiglitazone. Tell your doctor if you have a history of bone fracture, low calcium intake, or weak bones (such as osteoporosis). Tell your doctor right away if you experience any unusual bone pain. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Rosiglitazone while you are pregnant. It is not known if Rosiglitazone is found in breast milk. Do not breast-feed while taking Rosiglitazone.

Drug interactions

Some medicines may interact with Rosiglitazone. Tell your health care provider if you are taking any other medicines, especially any of the following: Insulin or nitrates (such as nitroglycerin) because the risk of heart problems may be increased; Gemfibrozil or oral ant-diabetic medicines (such as glipizide), because the risk of low blood sugar may be increased; Rifampin because it may decrease Rosiglitazone's effectiveness, resulting in high blood sugar; Anticoagulants (such as warfarin) because their effectiveness may be decreased, or the risk of their side effects may be increased by Rosiglitazone. If you are using any of the following drugs: gemfibrozil (Gemcor); rifampin (Rifater, Rifadin, Rimactane). You may not be able to take Rosiglitazone, or you may require a dosage adjustment or special monitoring.

If you take Rosiglitazone with other drugs that raise blood sugar you may have hyperglycemia (high blood sugar). Below are listed drugs that can raise blood sugar: diuretics (water pills); birth control pills and other hormones; steroids (prednisone and others); seizure medicines (Dilantin and others); and diet pills or medicines to treat asthma, colds or allergies. phenothiazines (Compazine and others); thyroid medicine (Synthroid and others); isoniazid. You may also experience hypoglycemia (low blood sugar) if you are taking Rosiglitazone with other drugs that lower blood sugar. Below are listed some of these drugs: sulfa drugs (Bactrim and others); a monoamine oxidase inhibitor (MAOI); nonsteroidal anti-inflammatory drugs (NSAIDs); probenecid (Benemid). aspirin or other salicylates (including Pepto-Bismol); beta-blockers (Tenormin and others). Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without first consulting your doctor.

Missed dose

If you miss a dose of Rosiglitazone, take it as soon as possible. If it almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.


Store Rosiglitazone at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Do not store Rosiglitazone in the bathroom. Store away from heat, moisture, and light. Keep Rosiglitazone out of the reach of children and away from pets.